FBI Agent Flynn (Samuel L Jackson) is on a mission: transport federally protected witness from Hawaii to Los Angeles so the government can put a brutal mob boss behind bars. But, just as the
plane reaches 30,000 feet hundreds if venomous snakes are unleashed causing violent mayhem as the vicious predators attack everyone in sight. With the help of LA's leading snake expert on the ground; Flynn leads the other passengers on a desperate, action-packed fight for their lives.