Wild at Heart begins with the Trevanion family going about their lives in Bristol. Everything changes drastically when an abandoned monkey is brought into Danny's surgery. His wife Sarah suggests they go to Africa to rehabilitate the monkey in hopes that a holiday will bring the family closer together. The holiday becomes a permanent adventure and throughout the series we see the Trevanions settle into life in the bush and work to start up a game park. They're faced with plenty of challenges along the way including lethal snake bites, a deadly strain of anthrax, darting lionesses, missing children, uninvited guests, and a rival game park whose manager causes plenty of trouble when he can.