Craig Schwartz (John Cusack) is a struggling street puppeteer. In order to make some money, Craig takes a job as a filing clerk. One day he accidentally discovers a door... a portal into the brain of John Malkoich (played by John Malkovich)! For 15 minutes, he experiences the ultimate head trip – HE is being John Malkovich! Then he’s dumped onto the New Jersey turnpike! With his beautiful office mate Maxine (Catherine Keener) and his petobsessed wife (Cameron Diaz), they hatch a plan to let others into John’s brain for just $200 a trip.