An orphan from the tough streets of Cleveland, Irish Danny Greene (Ray Stevenson) rises from working longshoreman to union leader and mob ally. Forced out of the union by the feds, Danny starts anew as an enforcer for loan shark Shondor Birns (Christopher Walken), while still maintaining influence with mafia boss John Nardi (Vincent D'Onofrio).

With Detective Joe Manditski (Val Kilmer) in pursuit, Danny rapidly acquires his own power and places himself at odds with the Italians, who find him to be a very difficult man to kill. What follows is a bloody war that breaks out on the streets of Cleveland and gives it the name "Bomb City, U.S.A."

Based on a true story, Kill The Irishman is the saga of one man who embodies the Irish warrior mentality with a mixture of pride, brutality, ambition and principle, as he became a central figure in the '70s mob war that forever changed organized crime in America.