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Fred Flarsky (Seth Rogen) is a gifted and free-spirited journalist with an affinity for trouble. Charlotte Field (Charlize Theron) is one of the most influential women in the world. Smart, sophisticated, and accomplished, she's a powerhouse diplomat with a talent for...well, mostly everything. The two have nothing in common, except that she was his babysitter and childhood crush. When Fred unexpectedly reconnects with Charlotte, he charms her with his self-deprecating humour and his memories of her youthful idealism. As she prepares to make a run for the Presidency, Charlotte impulsively hires Fred as her speechwriter, much to the dismay of her trusted advisors. A fish out of water on Charlotte's elite team, Fred is unprepared for her glamourous lifestyle in the limelight. However, sparks fly as their unmistakable chemistry leads to a round-the-world romance and a series of unexpected and dangerous incidents.