The show follows the adventures of lovable oaf Peter Griffin (Seth MacFarlane) and his hilariously odd family of middle-class New Englanders. Lois (Alex Borstein) is Peter's loving wife, a former Miss Teen Rhode Island who rules the roost but is one step away from a nervous breakdown. Then there are their kids: frumpy 16-year-old Meg (Mila Kunis), the family's punching bag; 13-year-old Chris (Seth Green), a kid who doesn't understand girls, much less the evil monkey who recently emerged from his closet; and 1-year-old Stewie (MacFarlane), a diabolically clever baby whose burgeoning sexuality is very much a work in progress. Rounding out the Griffin household is Brian (MacFarlane), the family dog, a member of Mensa with a penchant for dry martinis and dumb blondes.

During the upcoming season, the Griffins and fellow Quahog residents attend a party at James Woods' mansion and are embroiled in a classic "whodunit" murder mystery. Meanwhile, Lois becomes a local sports hero, and Stewie works for Brian as his literary manager.