Set within the highly charged confines of individual psychotherapy sessions, In Treatment centers around Dr. Paul Weston (Gabriel Byrne) who continues to cope with the after-effects of his recent divorce, as well as his move to Brooklyn to continue his practice. In the midst of new emotional and physical challenges (including hand tremors he fears might be the onset of Parkinson's Disease, which killed his father), Paul will be treating three new patients (Debra Winger, Irrfan Khan, and Dane DeHaan), and will see a new therapist (Amy Ryan) in New York City.