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In season five, Supergirl faces threats, both new and ancient. National City becomes enthralled with addictive virtual reality technologies created by CatCo's charming-but-secretive new owner, Andrea Rojas. As Kara uses the power of the press to try to expose this danger, she must contend with challenges put up by rival reporter William Dey, renegade Martian Malefic J'onzz, a shadowy organization called Leviathan, and the shocking return of Lex Luthor who, in addition to his plot for world domination, seeks to claim the soul of Supergirl's best friend (and his sister) Lena. With humanity choosing to lose itself in technology, can Supergirl save the world yet again?