Junior Doctor Ruby Walker (Amrita Acharia) has fled a cold, grey England after a broken relationship and decided to fly off in search of adventure with a glamorous hospital job in tropical South India. Anticipating sunshine, palm trees, and picture-perfect beaches; prepared for sacred cows, tuk-tuks and Delhi-belly; what she doesn't expect is everything she finds at the under-resourced and over-worked Good Karma Hospital. Run by the no-nonsense Doctor Lydia Fonseca (Amanda Redman) the Good Karma Hospital turns no-one away locals, ex-pats or tourists. In the company of laidback, beach-bar owner Greg (Neil Morrissey), and tourists-turned residents Maggie and Paul (Phyllis Logan & Philip Jackson), Ruby adjusts to life in India as she realizes that the Good Karma Hospital may be more than just a rundown medical outpost it might just be home. In Series Two, we re-join the team a year later, where Dr. Fonseca is still a force to be reckoned with. She is determined to kick Ruby out of her comfort zone as a doctor but it may prove too much too soon when she makes a snap decision in a crisis that could cost a patient's life. Ruby also connects with her Indian heritage when a lost relative gets in touch, and her discovery brings her closer to Dr Varma. As we delve deeper into the Keralan sub-tropical paradise, excitement, despair, adventure and hardship are never far away, but a solution can always be found at The Good Karma Hospital.