A group of carousing American tourists is taking in the cultural landmarks of Paris when a chance encounter results in sightseer Andy McDermott (Tom Everett Scott) saving the life of Parisian Serafine Pigot (Julie Delpy). While on a date at a nightclub with Serafine, Andy is suddenly attacked and bitten by a werewolf. The next day he discovers that Serafine is also a lycanthrope, and that he is beginning his own gruelling, hirsute transformation into one of the fanged beasts.