Baron Frankenstein (Joseph Cotten) is hard at work trying to reanimate human tissue when his daughter, Tania (Rosalba Neri), comes home from university with a medical degree and announces that it has always been her intention to carry on her father's work. The baron is thrilled, but no sooner does he successfully reanimate his creature than it kills him and stalks off. Shocked but undaunted, Tania vows to create an even greater monster to destroy the first in revenge.