What's Up, Doc? joyously recaptures the bubbly style of 1930's screwball comedies - and firmly establishes Barbra Streisand and Ryan O'Neal as a romantic duo uniquely endearing in screen history. Included are a daffy luggage mixup plot, dippy dialogue exchanges, a marvelous example of the art of hotel-room demolition and one of the funniest chase sequences ever, all over San Francisco.