Deadpool is desperate to end it all, but his healing factor makes dying a near-impossibility. When Wade finds the one thing in the world that can kill him - a serum that permanently disables his regenerative abilities - he just might get his wish. But when his newfound ability to die makes Deadpool feel more alive than ever, his sudden lust for life gets him in hot water with everyone he crosses - including crime bosses, super villains, his fellow mercenaries and even a dual Beretta-wielding monkey! Can the Merc with a Mouth escape his pursuers and his pattern of insanity-fueled self-destruction, and finally live life to the fullest?