Will Andrews is no academic. He longs for wildness, freedom, hope and vigour. He leaves Harvard and sets out for the West to discover a new way of living.

In a small town called Butcher's Crossing he meets a hunter with a story of a lost herd of buffalo in a remote Colorado valley, just waiting to be taken by a team of men brave and crazy enough to find them. Will makes up his mind to be one of those men, but the journey, the killing, harsh conditions and sheer hard luck will test his mind and body to their limits.